Effect of Propolis and other Commercially Available Agents in Reducing Dentine Hypersensitivity: A Systemic Review and Meta-Analysis

Abstract

Background and Objectives: Dentin hypersensitivity is a common dental condition, causing sharp pain due to exposed dentinal tubules. Traditional treatments, including nerve-blocking and tubule-occluding agents, lack consensus on the most effective method. This study compares the efficacy of propolis, a natural substance, to commercially available treatments for reducing dentin hypersensitivity.

Methods: A systematic review and meta-analysis were conducted, following PRISMA guidelines, including randomized controlled trials (RCTs) comparing propolis-based products to control agents. Data were analyzed using Visual Analog Scale (VAS) scores, and study quality was evaluated with the Cochrane risk of bias tool. High heterogeneity was noted across studies due to variations in propolis concentrations, follow-up durations, and methodologies.

Results: Results showed no significant difference between propolis and control products (SMD 0.04, 95% CI -2.23 to 2.32). Propolis demonstrated prolonged effects, while control products provided immediate relief that diminished over time. High heterogeneity (I2= 98%) was observed.

Conclusion: In conclusion, propolis-based products may offer a natural alternative for managing dentin hypersensitivity. However, no significant difference was found compared to conventional treatments. Further high-quality studies are needed to confirm these results and assess the long-term efficacy of propolis, with an emphasis on standardizing methodologies.